Canine model of pacing-induced heart failure

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August undefined, 2024

WebBackground: The canine model of pacing-induced heart failure is characterized by an absence of ventricular hypertrophy despite severe hemodynamic stress and neurohormonal activation. Given the mode of ventricular pacing, hypertrophy might occur in the atrial appendage. Methods and results: Seventeen dogs underwent continuous right … WebTo further understand the cellular events and to clarify their role in the pathology of cardiac failure, we have examined mitochondrial enzymatic function and peptide content, and mitochondrial DNA (mtDNA) integrity in a canine model of pacing-induced cardiac failure. Methods: Myocardium and skeletal muscle tissues were evaluated for levels of ...

Large Animal Models of Heart Failure Circulation: Heart …

WebMar 20, 2001 · The canine pacing-induced heart failure model shows a pattern of E-C coupling changes similar to that of humans: I Ca,L of normal amplitude triggers Ca i transients and contractions much smaller than normal, whereas SR Ca uptake is markedly impaired. 11 The present study investigates whether the defect in E-C coupling is due to … WebAug 17, 2011 · In addition, Nikolaidis et al. reported a 31% reduction in GLUT4 translocation and subsequently decreased glucose uptake, which was attributed to myocardial insulin resistance in their canine model of pacing-induced end-stage HF. However, it should be noted that their animal model was paced for a shorter duration (35 days) and at a ... how to safely dispose of fire extinguishers

Biatrial appendage hypertrophy but not ventricular hypertrophy…

WebThe most well-characterized large animal model of DCM is the pacing induced tachycardia model. 35–44 First described by Whipple et al 35 … WebThis model typically produces heart failure as defined by an LV dP/dt max <1500 mmHg/s, end-diastolic pressure >25 mmHg, mean arterial pressure <85 mmHg, and an ejection … WebJun 1, 1999 · In the canine pacing model, we first reported the appearance of interstitial edema and disruption/disappearance of collagen fibers in the hearts of these animals as … how to safely dispose of gasoline

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WebFeb 1, 2004 · Heart failure was induced in 15 dogs over 27 days by rapid pacing (230 beats/min). Seven animals underwent sham surgery, and 8 animals received 3 transventricular Myosplint devices each. WebJan 15, 2016 · Background: Our aim was to assess how atrial fibrillation (AF) induction, chronicity, and RR interval irregularity affect left atrial (LA) function and size in the setting of underlying heart failure (HF), and to determine whether AF effects can be mitigated by vagal nerve stimulation (VNS). Methods: HF was induced by 4-weeks of rapid … how to safely dispose of fluorescent tubesWebAtrial fibrillation (AF) is commonly associated with congestive heart failure (CHF), and CHF has been shown to be associated with atrial structural remodeling resulting in fibrosis. Atrial interstitial fibrosis has been seen in patients with CHF and in animal models of pacing-induced heart failure. … how to safely dispose of nuclear waste

"WebMar 19, 1999 · Pacing-induced heart failure in the dog recapitulates many of the electrophysiological and hemodynamic abnormalities of the human disease; however, the mechanisms underlying altered Ca2+ handling have not been investigated in this model. " - Canine model of pacing-induced heart failure

Canine model of pacing-induced heart failure

Frontiers Large Animal Models of Heart Failure With …

WebHeart failure with reduced ejection fraction (HFrEF) is defined by an ejection fraction (EF) below 40%. Many distinct disease processes culminate in HFrEF, among them acute and chronic ischemia, pressure … WebMay 10, 2016 · In pacing-induced canine models of heart failure, marked upregulation of adenosine A1 receptors occurs with increased sensitivity to adenosine induced SN dysfunction and AF. 67. Download figure; Download PowerPoint; Figure 4. Rhythm strip showing the effect of adenosine on the sinus node and atrium. Intravenous adenosine …

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WebThe aim of the study was to use the isolated blood-perfused rat heart to: (i) determine whether brief intermittent rapid pacing and ventricular fibrillation ar 掌桥科研一站式科研服务平台 WebChronic rapid ventricular pacing (250 beats/min) induces severe heart failure in a canine model. To assess the potential for recovery after cessation of pacing, simultaneous hemodynamic and two-dimensional echocardiographic studies were conducted in nine conscious dogs paced to severe heart failure (4.3 +/- 1.7 weeks).

WebFeb 18, 2014 · Some patients even develop severely depressed LV function within a short time frame, a condition that has been coined ‘dyssynchronopathy’ in a canine model of AV block that develops rapid heart failure. 10 Development of a dyssynchronopathy might also explain the well-known but ill-defined group of super-responders to CRT. 11 It should be ... WebJul 10, 2024 · The development of pacing-induced heart failure was studied in chronically instrumented, conscious dogs paced at a rate of 240 beats/min for 1 d (n = 6), 1 wk (n = …

WebJul 1, 2024 · The cardiac effects of pimobendan (but not amrinone) are preserved at rest and during exercise in conscious dogs with pacing-induced heart failure. J Pharmacol … WebJun 13, 2005 · Animal Model Preparation. All procedures were approved by the Indiana University Institutional Animal Care and Utilization Committee. The study was performed in a canine model of healed myocardial infarction (MI) and pacing-induced heart failure (HF) that was shown to have a high incidence of spontaneous ischemic ventricular …

WebApr 12, 2024 · Liu et al. used a rapid pacing model in vitro and a canine model of rapid pacing to establish the implication of miR-23a-3p in ferroptosis during AF. ... Yanni et al. used an animal model of heart failure that developed sinus bradycardia to demonstrate the function ... Lower levels of cardiac fibrosis are clinically associated with drug-induced ...

WebTachypacing-induced heart failure is a well-established large animal model that recapitulates numerous pathophysiological, structural and molecular features of dilated … how to safely download a fileWebThe mechanisms of sinoatrial node (SAN) dysfunction in heart failure (HF) remain unclear. We hypothesized that impaired rhythmic spontaneous sarcoplasmic reticulum Ca(2+) … how to safely dispose of toner cartridgeWebFeb 18, 2014 · In addition, a model of pacing-induced heart failure was employed to examine conditions of CHF and the results may be different in heart failure of a different origin. Conclusion. The present data demonstrate for the first time that a fast phase-III repolarization was associated with a low proarrhythmic potential in CHF, whereas a more … how to safely dispose of old road flaresWeb20 hours ago · Abnormal mitochondrial function in myocardium of dogs with chronic heart failure. J Mol Cell Cardiol. 1998; 30:1757–1762. doi: 10.1006/jmcc.1998.0739 Crossref Medline Google Scholar; 105. Marin-Garcia J, Goldenthal MJ, Moe GW. Abnormal cardiac and skeletal muscle mitochondrial function in pacing-induced cardiac failure. … how to safely dispose of sulfuric acidWebChronic heart failure is a clinical syndrome with multiple etiologies, associated with significant morbidity and mortality. Cardiac arrhythmias, including ventricular tachyarrhythmias and atrial fibrillation, are common in heart failure. A number of cardiac diseases including heart failure alter the expression and regulation of ion channels and … how to safely dispose of old medicationWebIn studies aimed at characterizing the canine pacing-induced heart failure model further, it was demonstrated that atrial ERP was unchanged prior to the initiation of AF (Li et al., 1999). The extent of atrial fibrosis, however, was increased dramatically (from 0.3% in control to ∼15% in animals in congestive heart failure), a structural ... how to safely dispose of unused matchesWebBackground Heart failure increases autonomic nerve activities and changes intracellular calcium (Ca i ) dynamics. Objective The purpose of this study was to investigate the hypothesis that abnormal Ca i dynamics are responsible for triggered activity in the pulmonary veins (PVs) during acetylcholine infusion in a canine model of heart failure. northern tools fans