Fxr and obesity

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August undefined, 2024

WebJun 20, 2011 · Contradictory to our observation that FXR deficiency is beneficial for glucose homeostasis in obesity, FXR activation has been shown to improve insulin resistance in rodent models of diabetes (8,31,33). The reason for this apparent inconsistency is currently unclear. However, the pharmacological activation of a nuclear receptor does not ... WebMay 14, 2024 · Obesity is a major epidemic and results in adipose tissue expansion and dysregulated glucose and lipid metabolism. Farnesoid X receptor (FXR) is a nuclear receptor expressed in many tissues that transcriptionally regulates energy homeostasis. However, the role of FXR in adipose tissue remains elusive.

FXR Regulates Adipose Tissue Remodeling during Obesity

WebFeb 10, 2024 · The FXR-SHP-miR-802 pathway may present novel targets for treating obesity-related diabetes and fatty liver disease. The Kemper lab also found that in obese mice, activation of FXR via obeticholic acid (OCA) treatment reduced miR-802 levels and improved insulin resistance and fatty liver and that these effects were nullified by the ... WebMar 1, 2015 · FXR, obesity and T2D. The global prevalence of diabetes in 2010 was 280 million people worldwide (around 6.2% of the world׳s total population), and it has been predicted that in 2030 the prevalence will reach more than 7.5% of the world׳s total population, paralleling the aging and body mass index (BMI) of the population. luxcary cars from 1930 to 1940

FXR activation improves myocardial fatty acid metabolism in a …

WebMar 25, 2024 · Several groups have investigated the role of BA–FXR signalling in obesity and reported that FXR deficiency decreased body weight gain and fat mass in both … WebUpon activation by bile acids, FXR controls the expression of many genes involved in bile acid, lipid, glucose and amino acid metabolism. An inability to properly use and … WebJan 6, 2016 · Results. The gut microbiota promoted weight gain and hepatic steatosis in an FXR-dependent manner, and the bile acid profiles and composition of faecal microbiota differed between Fxr−/− and wild-type mice. The obese phenotype in colonised wild-type mice was associated with increased beta-cell mass, increased adipose inflammation, … jean marc focus on you

Intestinal FXR agonism promotes adipose tissue browning and ... - Nature

WebIn the present study we have investigated whether administering obese (fa/fa) Zucker rats, a genetic model of obesity associated with dyslipidemia and insulin resistance, with an FXR ligand protects against lipid-induced cardiomyopathy. WebJan 11, 2024 · Clinical studies focusing on FXR and TGR5 have shown interesting results. For example, FXR- and TGR5-agonist obeticholic acid was used in human trials, showing a positive effect on plasma lipids. However, it also had dose-dependent side effects , the most common of which was intolerable pruritus. More worrisome is the fact that obeticholic … luxchem corporation bhdWebActivation of FXR is believed to improve insulin and glucose sensitivity in patients with diabetes and non-alcoholic fatty liver disease (Li and Chiang, 2014). It is controversial that intestinal FXR deficiency or antagonism could improve obesity, insulin resistance and NAFLD (Jiang et al., 2015); (Zhong et al., 2024). jean marc gheraille

"WebUrsodeoxycholic acid exerts farnesoid X receptor-antagonistic effects on bile acid and lipid metabolism in morbid obesity These data demonstrate that by exerting FXR-antagonistic effects, UDCA treatment in NAFLD patients strongly impacts on cholesterol and BA synthesis and induces neutral lipid accumulation in both liver and vWAT. " - Fxr and obesity

Fxr and obesity

Bile Acids, FXR, and Metabolic Effects of Bariatric Surgery

WebNov 5, 2024 · Furthermore, inhibition of intestinal FXR prevented obesity-related metabolic dysfunction in mice 23,24,25,26. However, human and mouse bile acid profiles are known to differ, ... WebJan 6, 2016 · Results. The gut microbiota promoted weight gain and hepatic steatosis in an FXR-dependent manner, and the bile acid profiles and composition of faecal microbiota …

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WebJan 25, 2012 · The nuclear bile acid receptor, farnesoid X receptor (FXR), is an important transcriptional regulator of liver metabolism. Despite recent advances in understanding its functions, how FXR regulates genomic … WebDec 15, 2015 · The high-affinity FXR agonist GW4064 blocks Gly-MCA action in the gut, and intestine-specific Fxr-null mice are unresponsive to the beneficial effects of Gly-MCA. ... (FXR) agonist induces obesity ...

WebHigh-fat diet-fed intestine-specific Fxr-null (Fxr(ΔIE)) mice show lower diet-induced obesity, similar to tempol-treated wild-type mice. Further, tempol treatment does not decrease weight gain in Fxr(ΔIE) mice, suggesting that the intestinal FXR … WebJan 5, 2015 · Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance Nature Medicine Published: 05 January 2015 Intestinal FXR agonism promotes adipose...

WebFeb 10, 2024 · Both activation of hepatic FXR and inhibition of intestinal FXR have beneficial effects on obesity-related metabolic diseases. As a transcriptional factor, FXR directly … WebNov 8, 2016 · Male mice are more sensitive to diet-induced obesity and diabetes than female mice, and thus male mice were used in this study. Six- to eight-week-old male littermate Fxr fl/fl and Fxr ∆IE mice ( 11) were fed an HFD and gavaged with vehicle or CAPE (75 mg/kg/day) for 4 weeks.

WebThus, modulation of bile acid levels and signalling, using bile acid binding resins, TGR5 agonists, and FXR agonists, may serve as a potent therapeutic approach for the treatment of obesity, type 2 diabetes, and other components of the metabolic syndrome in humans.

luxchem corporation bhd stock priceWebFigure 1. Farnesoid X receptor (FXR) and the gut microbiota regulate development of diet-induced obesity. (A) Weight gain of 9-week to 14-week old germ-free (GF) and CONV-R wild-type and Fxr−/− male mice … luxchoice watchesWebSep 2, 2016 · Using wild type (WT) and intestine-specific FXR knockout (FXR int−/−) mice, we found that BBR prevented the development of high-fat-diet–induced obesity and ameliorated triglyceride accumulation in livers of WT, but not FXR int−/− mice. BBR increased conjugated bile acids in serum and their excretion in feces. luxcherie shade nails harahanWebApr 4, 2024 · FXR regulates the expression of CYP7A1 through a feedback mechanism by increasing BAs after food intake . FXR serves as the primary target of most BAs. ... Activation of PXR prevents high-fat diet- and obesity-induced insulin resistance by regulating energy and lipid metabolism . Vitamin D (VD) deficiency may lead to bone and … luxchem tradingWebFurther analyses of randomly selected genes from both healthy and obese mice suggested that more FXR-binding sites are likely functionally inactive in obesity. Surprisingly, occupancies of FXR, retinoid X receptor alpha, RNA polymerase II, and epigenetic gene activation and repression histone marks, and messenger RNA levels of genes examined ... luxciole by hisleWebMar 1, 2024 · Targeting FXR and TGR5 signaling has been shown to improve hepatic bile acid metabolism and lipid and glucose homeostasis to prevent progression of NASH in clinical trials. Both activation and antagonism of intestinal FXR alleviate diet-induced obesity and diabetes. Table 1 summarizes bile acid-based therapies for NAFLD. luxcine 4k smart wifi projectorWebAcetaminophen (APAP) toxicity is a common cause of hepatic failure, and the development of effective therapy is still urgently needed. Farnesoid X receptor (FXR), a member of the nuclear receptor superfamily, has been identified as a master gene for regulating enterohepatic metabolic homeostasis and has proven to be a promising drug target for … jean marc gaspard itard pronounce