Web17 okt. 2006 · Description. An autosomal dominant disorder that involves an overlapping but variable spectrum of central nervous system and ocular developmental anomalies. … WebBackground/aims To identify KIF11 mutations in patients with familial exudative vitreoretinopathy (FEVR) and to describe the associated phenotypes. Methods Mutation analysis in a cohort of patients in a single institute was conducted. Bioinformatics was performed for whole exome sequencing, and the variants were confirmed by Sanger …
KIF11 inhibitors filanesib and ispinesib inhibit meningioma growth
WebAdenomatous polyposis coli (APC) also known as deleted in polyposis 2.5 (DP2.5) is a protein that in humans is encoded by the APC gene. The APC protein is a negative regulator that controls beta-catenin concentrations and interacts with E-cadherin, which are involved in cell adhesion.Mutations in the APC gene may result in colorectal cancer.. APC is … WebKif18A/kinesin-8, an essential regulator of kinetochore MT dynamics, accumulates at its plus-ends in metaphase but not prometaphase cells. The underlying mechanism of time-dependent and kinetochore MT-specific plus-end accumulation of Kif18A is unknown. Here, we examined the factors required for the MT plus-end accumulation of Kif18A. charter fishing cedar key fl
Structural basis of human kinesin-8 function and inhibition
Web25 okt. 2024 · KIF11 is a motor protein best known for its role in mitosis or cell division in non-neuronal cells. But it also plays a critical role in the formation of the dendrites and dendritic spines of... Web25 okt. 2024 · Increased KIF11/kinesin-5 expression offsets Alzheimer Aβ-mediated toxicity and cognitive dysfunction. iScience , 2024; 25 (11): 105288 DOI: 10.1016/j.isci.2024.105288 Cite This Page : WebIn order to identify the potential regions of KIF11 that recognize and interact with ZBP1, we dissected KIF11 protein structure, generated various truncated KIF11 cDNAs by PCR and subcloned the ... curriculum reforms in science education